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Centers

DCR provides a variety of consultations and services to assist investigators and staff with specific projects. All consultations are free.
Bioinformatics Consortium
Computational data management, analysis, and interpretation have become both a major driver and major bottleneck in many areas of biomedical research.

The goal of the Massachusetts General Hospital Bioinformatics Consortium is to provide bioinformatics and wider genomics service, consulting, education and training for biological, preclinical and clinical investigators at Mass General and in the broader research community.

Through service and collaboration with partners from academia and industry, we develop and support the informatics component of fundamental, translational and clinical research projects.

Combined with our wet-lab capabilities for next-generation sequencing, this service provides a fully integrated resource for genomics studies in both preclinical and clinical settings. Through consulting, we help our partners design and execute experimental or clinical data generation and management, as well as implement best practices for quantitative analysis in order to produce powerful and relevant biomedical data. Through educational outreach, we educate our partners in general Bioinformatics concepts and methods, and help them think about the data in quantitatively rigorous terms. Through training, we help researchers acquire hands-on computational skills in basic statistics, experimental design, and Bioinformatics workflows.

The Consortium includes highly acclaimed groups associated with Massachusetts General Hospital, Harvard Medical School, and Broad Institute, with outstanding record of both collaborative and independent Bioinformatics research.

Our expertise covers all major aspects of project workflow in both fundamental and clinical Bioinformatics: experimental/study design, high-throughput data generation, large-scale data management, state-of-the-art computational analysis, interpretation of the results in the context of specific project goals, and presentation of findings and hypotheses for further experimental or clinical validation.

Examples of our major areas of expertise include:
  • Next-generation sequencing of biological and clinical samples: whole genome and targeted sequencing, profiling of gene expression, DNA methylation, chromatin modifications etc.
  • Genome variant and gene expression analysis; interpretation of the results in the clinical context of disease and pharmacogenetic response
  • Visualization and annotation of genome variants and other genomic data using custom knowledge management platforms
  • Biomarker discovery, development of sequence-based genetic diagnostic tests
  • Analysis of genome-wide patterns of DNA and chromatin modifications, protein DNA binding, and chromatin interactions in wider contexts of publicly available biomedical data
  • Analysis of protein sequence, structure, and molecular pathways
  • Development of data management solutions for complex genomics and drug discovery assay datasets
  • Development of platforms for collective management, sharing, and analysis of information related to collaborative clinical studies and specimen bio-repositories available to project stakeholders and broader research community
  • Development of custom knowledge bases of diseases based on large-scale curated literature analysis and public biomedical databases
Biostatistics Center
The mission of the Center is to engage in impactful trans-disciplinary collaborations involving quantitative methods in public health and biomedicine.

Our faculty and staff develop, evaluate and apply rigorous statistical and data science methods across a broad spectrum of research areas. These include studies in cancer, cardiology, emergency medicine, psychiatry, pediatrics, infectious diseases, neurology and many other areas of clinical and translational research. We have shared expertise in methods for clinical trials, observational studies, clustered and longitudinal data, missing data, survival analysis, machine learning, genetics and genomics, implementation science, and precision medicine applications.

The Biostatistics Center partners with the Mass General Division of Clinical Research, the Harvard Catalyst Program, the Harvard Cancer Center, and the Mass General Mongan Institute. We are home to a data coordinating center for Acute Respiratory Distress Syndrome and a Rare Cancer Genetics Registry. Our members are also engaged in local and global educational initiatives focused on contemporary biostatistical methods and state-of-the-art data science tools.

We always welcome new collaborations!
Center for Clinical Research Education
The Center for Clinical Research Education (CCRE) offers courses and seminars to address the unique and rapidly changing needs of the Massachusetts General Hospital clinical research community.

Resources:
Center for Qualitative Health
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The Center for Quantitative Health facilitates investigations drawing on large clinical databases, most notably large-scale electronic health records (EHR).

Services:
  • Consultation with investigators to plan and refine investigations making use of large clinical datasets;
  • Assistance in preparation of materials describing investigations of large clinical data sets for submission to IRB or other regulatory review;
  • Assistance in generating descriptions of methods for incorporation in funding applications;
  • Assistance in generating pilot data to motivate funding applications, and for incorporation in publications;
  • Development of tools to allow researchers to address questions which would otherwise be difficult to study in large data sets;
  • Assistance in accessing appropriate large data sets and integration of multiple data sets – for example, use of birth and death certificate data;
  • Assistance in development of decision support tools which make use of results derived from large clinical data sets.
Clinical Research Center
TCRC Website
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Contact the CRC by phone: 617-726-3294

The Massachusetts General Hospital Translational and Clinical Research Center (TCRC) offers administrative and nursing services as well as metabolic and nutritional research information for our investigators.

TCRC Departments:
  • Administration
  • Nursing
  • Metabolism and Nutrition Research
  • TCRC Processing Lab
Mass General TCRC Study Locations:
  • White 12
  • White 13
Community Access, Recruitment, & Engagement Research Center
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Our Mission:

The Community Access, Recruitment, and Engagement (CARE) Research Center at Massachusetts General Hospital aims to ensure that advances in medicine work for everyone. CARE is focused on creating a clear, testable science of research engagement, recruitment, and retention. This framework is based upon community-led partnerships as the foundation for health equity. We are committed to ensuring that these principles and practices are rooted in diverse and inclusive research design.

To visit the MGH CARE Research Center full website please click here

About CARE:

The Community Access, Recruitment & Engagement (CARE) Research Center at Massachusetts General Hospital was founded by Jonathan Jackson, PhD, in 2017 with the aim to improve representation in clinical trials at the hospital. We focus on disparities for underrepresented groups in clinical trials, including racial and ethnic minorities, LGBTQ+ groups, rural populations, individuals of low socioeconomic status, and identities that intersect with these areas.

In bringing clinical research into the community in a way that engages and enables the community to co-lead and contribute to these research endeavors, CARE sets the stage for a paradigm shift in the language, practice and design of clinical trials. Such changes will have a multiplier effect, forging a new landscape for clinical trial participation in Boston and beyond which will ultimately improve the validity of life-saving research related to a range of diseases and disorders.

CARE has three intersecting areas of interest:
  1. A quantified, testable science of engagement, recruitment, and retention to research studies
  2. Strong, sustained, reciprocal community engagement and partnership
  3. A robust network of researchers, clinicians and community voices to ensure that cutting-edge medicines can effectively reach those who need it most
Through research on clinical trials as well as broad and sustained community engagement, we hope to reengineer the process behind clinical trial engagement, recruitment, and retention to support the inclusion of diverse and marginalized groups. CARE works to achieve this aim by:
  • Leveraging a community-led collective impact model to develop and engage in sustained local partnerships in underserved areas of Boston
  • Improving health, medical, research and insurance literacies
  • Focusing on research engagement within vulnerable communities, ensuring that studies provide a strong return of value for underserved groups
  • Streamlining the clinical trial recruitment process at Massachusetts General Hospital through staff training and consultancy
  • Facilitating collaboration across the United States via robust clinical and research networks to improve inclusive access to its clinical trials
Munn Center for Nursing Research
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MGH Clinical Research Nurses

The Munn Center supports nursing research initiatives that advance clinical practice and optimize quality patient-centered outcomes.

The Yvonne L. Munn Center for Nursing Research, housed within the Institute for Patient Care, was inspired by the vision and dedication of Yvonne L. Munn, RN, MSN, a nurse leader at Massachusetts General Hospital from 1984-1993, and her desire to advance nursing research at Mass General.

The official dedication of the Munn Center in May 2008 acknowledged the hospital’s commitment to nursing and interdisciplinary research collaborations that foster high quality, cost-effective, patient and family-centric care.

Goals of the Center:
  • Accelerate research in core areas of focus: care of the elderly, ethics, symptom management, workforce evaluation, and complementary interventions to enhance healing and recovery.
  • Design strategies to promote the development, use, and translation of evidence into practice.
  • Foster innovation through the establishment, implementation and evaluation of interventions that promote changes in care delivery
  • Implement mentoring strategies to support a research agenda for all nurses in Patient Care Services (PCS)
  • Collaborate with other centers within the Institute for Patient Care to advance the strategic mission of PCS
  • Generate new partnerships and funding mechanisms within Mass General and with external funding sources
  • Actively participate in the Executive Committee on Research (ECOR) and the Mass General Research Council to develop new collaborative opportunities across disciplines
  • Enhance visibility of research conducted by nurses at Mass General through dissemination in high-impact journals and presentation at internal and external scientific meetings
Research Areas of Interest:
  • Complementary therapies
  • Geriatrics and care of the elderly
  • Quality and safety of care delivery
  • Transitional care
  • Ethics and clinical decision making
  • Innovation science
  • Symptom management
  • Workforce evaluation
Methods:
  • Electronic medical record evaluation
  • Qualitative methodology
  • Systematic reviews
  • Instrument development and evaluation
  • Quantitative methodology
Mass General Brigham Biobank at Mass General
The state-of-the-art Mass General Brigham Biobank at Massachusetts General Hospital provides researchers with access to high-quality samples to help foster research and advance the practice of medicine and our understanding of the causes of common diseases.

Researchers and clinicians at Massachusetts General Hospital, Brigham and Women’s Hospital (BWH) and other Mass General Brigham institutions are studying how genes, lifestyle and other factors affect people’s health and contribute to disease.

To do this research, we are asking patients at Mass General Brigham hospitals to participate in the Mass General Brigham Biobank (Mass General Brigham Biobank).

This state-of-the-art biobank will help researchers uncover the links between an individual’s genetics, family history and environment in the development of disease and in people’s response to medications. The Mass General Brigham Biobank will help bring us one step closer to preventive and personalized medicine.

Join our Biobank

To join the Mass General Brigham Biobank, patients are asked to provide a small blood sample that will be linked to health information and family history data and stored in a research sample and data repository.

In order to join the Mass General Brigham Biobank, you need to be:
  • At least 18 years old
  • A patient at Mass General or BWH
Learn more about the biobank

If you are not currently a patient at one of our participating institutions, but are still interested in joining, please contact our staff to find out more.

For Investigators

Please visit Mass General Brigham Personalized Medicine for information on how to obtain samples and how to collaborate with the Mass General Brigham Biobank.

You can also get started by sending us an email. Our staff will guide you through the process.
Pediatric Translational Research Center
The Pediatric Translational Research Center (PTRC) was founded to develop effective new personalized and preventative strategies for disorders starting in childhood.

Mission

The research mission of Pediatric Translational Research Center (PTRC) is to advance translational fundamental, clinical and population science related to the health and development of infants, children and adolescents. Research at MassGeneral for Children recognizes the challenges and opportunities for child health research dictated by the changing social, economic and health care policy landscape in the US, including the shift toward Precision Medicine. Across the Department, our research integrates multidisciplinary clinical and scientific expertise with local, regional, national and international collaborations.

Focus

Our focus is to develop new effective strategies for personalized and preventive medicine. The advent of genomics, proteomics, and now microbiome analysis raised the expectation of therapeutic solutions that never materialized. It is now becoming clear that many diseases affecting humankind are final destinations, but the path to disease development can be different from patient to patient. Unfortunately, the complexity, the multi-factorial nature and, most importantly, the lack of information on the environmental factors triggering the disease process have hampered the progress in defining host-environmental interactions causing disease in genetically susceptible individuals.

Strategic Priority

With the appreciation that the biological events in childhood can strongly influence disease onset in both childhood and adulthood, we intend to expand our integrated models focused on pre-clinical/early and translational clinical studies to provide the rationale of possible therapeutic and/or preventive interventions. Our strategic priority is to increase PTRC visibility and branding to expand our current research portfolio in order to become a unique asset complementary to the overall mission of the DCR and the Mass General Research Institute as a whole.

Goals

Our overarching goal is to improve the lives of children and families through science. A current strategic priority is to develop new effective personalized and preventive strategies for disorders starting in childhood by integrating multi-level, multisystem data ranging from the molecular to the whole child in order to prevent or reverse development of disease.
Translational Research Center
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The Translational Research Center at Massachusetts General Hospital is a new 18-bed clinical research facility dedicated to first-in-patient clinical trials in collaboration with industry.

The Translational Research Center (TRC) is a new clinical trial facility located in the heart of the Massachusetts General Hospital campus.

The TRC is focused on the recruitment of patients into early stage proof-of-concept trials. This is different from trials run by many contract research organizations, which typically recruit healthy human volunteers.

Early treatment of patients with a potential therapeutic provides evidence for efficacy in the target treatment population. It also allows measurements of key biochemical, genetic, and radiological parameters to be made in affected individuals.

About Our Center

The TRC offers all the advantages of an inpatient hospital care in a setting that is specialized for clinical research.

The center includes 18 inpatient beds and four infusion chairs. Each bed has central monitoring and oxygen at the headwall. There are two private rooms with air flow monitoring suitable for studies involving gene therapy vectors or other agents where containment of biological materials is critical.

The TRC staff includes expert research nurses, nurse practitioners, research nutritionists, laboratory technicians, and project managers. Both adult and pediatric study participants can be accommodated.

The laboratory and imaging technical capabilities of the hospital (e.g., genomics, specialized immunological assays, PET scanning) are available to illuminate key research questions.

The TRC can draw from a pool of 3 million patients cared for in the Mass General/Mass General Brigham system and match them with the right clinical investigator from the 2,500 physician scientists at Mass General, who are leading experts in their respective disciplines.